| Specification | Ducati Multistrada V4 RS | Ducati Multistrada V4 Pikes Peak |
| Engine | Desmosedici Stradale 1,103cc, V4 | Granturismo 1,158cc, V4 |
| Power | 180 horsepower (at 12,250 RPM) | 170 horsepower (at 10,500 RPM) |
| Torque | 87 pound-feet (at 9,500 RPM) | 92 pound-feet (at 8,750 RPM) |
| Compression ratio | 14:1 | 14:1 |